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Aphrodisiac activity of aqueous and hydroethanolic extracts of the stem bark of strychnos camptoneura (longaniaceae) in wistar rat

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Author: 
Cyr Jonas Morabandza, Radard Ondele, Romaric De Garde Elion Itou, Arnaud Wilfrid Etou Ossibi, Céty Imbiella, Etienne Mokondjimobe, Pascal Robin Ongoka and Ange Antoine Abena
Abstract: 

This study was initiatedto evaluate aphrodisiac activity of aqueous and hydro-ethanolic extracts of the stem bark of Strychnos camptoneura in male rat. Aqueous and hydroethanolic extracts of S. camptoneura were prepared and, orally administered at the doses of 100 and 250 mg/kg for sexual parameters (sexual mounting; erection number; ejaculationnumber and latency time) evaluation. Distilled water (0,5ml/100g) and yohimbine (10mg/kg) being respectively negative and positive control. Aphrodisiac effect mechanisms were studied in the presence of L-NAME, Haloperidol and Atropin. Obtained results revealed that aqueous and hydroethanolic extracts of S. camptoneura at the doses of 100 and 250 mg/kg act favorably and significantly on sexual parameters (sexual mounting; erectionnumber; ejaculation number and latency time) in male rat. The two extracts would act by dopaminergic and cholinergic way. The preliminary results thus obtained explain the traditional use of the stem bark of S. camptoneura in sexual purposes and could constitute a good remedy in the treatment of erectile dysfunction.

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