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A comparative study of moisture sorption on hICELTMSMCC, HICELTMMCC and physical blend of HICELTMMCC and colloidal silicon dioxide, formulation and evaluation of dispersible tablet of acetyl salicylic acid

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Author: 
Monika Tomar, Amit Raj Sinha and Ajay Kumar Singh
Abstract: 

Moisture content is a critical parameter for manufacturing oral solid dosage forms. It should be maintained as per requirement moisture content beyond the limits of less than 4% or higher than 5.5% affect tablet properties i.e. hardness, friability and disintegration time. In this article, we will done comparative study of moisture sorption on HiCelTM MCC 90M (Microcrystalline cellulose), HiCelTMSMCC 90M (Silicified Microcrystalline cellulose) and physical blend of HiCelTMMCC 90M(Microcrystalline cellulose) and colloidal silicon dioxide and also discuss manufacturing process of HiCelTMMCC 90M, HiCelTMSMCC 90M and Physical blend with HiCelTMMCC and Colloidal silicon dioxide. We will make dispersible Acetyl salicylic acid tablet using them and evaluate the comparative study. HiCelTMSMCC 90M would show improved tablet properties in terms of better compaction, hardness, friability and disintegration than HiCelTMMCC 90M and physical blend of HiCelTMMCC and Colloidal silicon dioxide.

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