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Dissolution enhancement of itraconazole by liquisolidcompactstechniques And its in-vitro evaluation

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Author: 
Pawar J.D., Mr. Jagtap R.S., Dr. Doijad R.C., Me. Desai J. R., Ms. Pol S.V., Ms. Jadhav V.V., Mrs. Jagtap S.R. and Mr. Shete A.S.
Abstract: 

Background: Itraconazole model drug, since it is insoluble in water. Itraconazole pure drug is a potent synthetic triazole antifungal drug with activities against broad spectrum of fungal species. It is hydrophobic drug which belongs to BCS class II and its half-life is 21h with 55% bioavailability. Attempt had created to examine the use of liquisolid technique in raising the dissolution of Itraconazole in a solid dosage form.
Methods: The liquisolid tablets were formulated by using PEG 400, as liquid vehicle, microcrystalline cellulose as a carrier material, silica as a coating material and sodiumstarch glycolate used as a super disinter grant. The new mathematical model and 32 fullfactorial design was utilized to formulate various liquisolid powder systems.
Result and discussion: All prepared liquisolid batches were subjected to, weight variation, drug content uniformity, hardness, friability test, disintegration test and dissolution tests. Liquisolid system is also tested for DSC, XRD and IR .All the tested liquisolid tablet formulations showed higher drug dissolution than the conventional, directly compressed tablet.
Conclusion: DSC and XRD study recommended loss of Itraconazole crystallinity upon liquisolid formulation; it indicates that drug is held within the powder substrate during a solubilized, nearly molecularly distributed state, which lead to the improved drug dissolution properties.

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               Prof. Dr. ISMAIL YILDIRIM

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