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An efficient domino one-pot, four-component green chemical approach for the synthesis of structurally diverse dihydropyridine fused medicinally privileged heterosystems

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Author: 
Suresh Rai, Rekha Israni and Dilip Kumar Khatri
Abstract: 

The derivatives of structurally diverse dihydropyridine fused hetrocycles; 2,3-quinolinedicarboxylate,chromeno[4,3-b]pyridine-2,3-dicarboxylate, pyrido[2,3-d]pyrimidine-6,7-dicarboxylate, pyrano[4,3-b]pyridine-2,3-dicarboxylate incorporating medicinally privileged fused heterosystems have been synthesized by an environmentally benign, efficient and convenient synthesis involving the Iron(III)chloride-catalyzed four-component domino reaction of aromatic aldehydes, acetylenedicarboxylate and arylamines with cyclic 1,3- dicarbonyl compound in an ethanol medium. The selective formation of the very different pyridine fused heterocyclic derivatives depends on the structure of cyclic 1, 3-dicarbonyl compound.

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               Prof. Dr. ISMAIL YILDIRIM

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