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Exploring anticancer activity of topically applied quinine sulfate on skin carcinoma - Biochemical study of skin

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Author: 
Deepika Jhanwar and Jaimala Sharma
Abstract: 

In this study DMBA was used as skin carcinoma initiator and Croton oil was used as promoter. Quinine sulfate was topically applied on mice skin to treat skin carcinoma. Quantitative estimation of catalase activity, superoxide dismutase activity, reduced glutathione, vitamin –C content and lipid peroxidation was performed in mice skin. In this study antioxidative capacity of all the groups of mice, which were given Quinine sulphate with carcinogen, was more than the group, which was given carcinogen only. Because GSH, SOD activity, catalase activity, vitamin-C and total protein content were found increased and LPO reduced in comparison to carcinogen treated positive control group of mice. After further research this finding may prove to be useful for topical treatment of skin cancer.

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