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Overview of metal-organic framework based drug delivery systems

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Author: 
Smita Nayak, Shivali Singh and Vaidhun Bhaskar
Abstract: 

While the last few decades have brought about significant advances in the area of novel drug delivery systems, there is still scope for further research. One of the areas that is gaining prominence is Metal Organic Frameworks (MOFs), a class of compounds that is exhibiting potential in drug delivery. MOFs are coordination polymers, new class of highly tunable hybrid materials self- assembled from organic bridging ligands and metal ion cluster connecting points that display permanent porosity, thus showing great promise for myriad of applications in biomedicine, gas storage, catalysis, separation and sensing. Scaling down these materials to nano sizes has conferred potential advantages such as structural and chemical diversity, high loading capacity and intrinsic biodegradability. In this review article, we will be mainly focusing on design and development of MOFs. Also we will be focusing on recent developments with respect to drug delivery, encapsulation and surface modification for MOF/nanoMOF and their future prospects.

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