Sterculia setigera is a widely used plant for numerous herbal preparations. There are various folkloric claims for its use for the treatment of many diseased conditions. Examination of theanti-diarrhoeal effect of stem-bark ethanolic extract of Sterculia setigera was carried out. Results showed that extract has an inhibitory effect on castor oil diarrhoea– induced mice (Mus musculus), with 0.5ml/10g (9.01± 1.07) and 0.1ml/10g (1.83 ± 0.41) respectively. Inhibitory activity was characterized by steady decline in the diarrhoeal episode commencing at 56% thus, confirms Sterculia setigera as such with antidiarrhoeal activity.
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