In present study Di (2-ethyylhexyl) phthalate orally administered at the dose of 10 mg/kg/b.wt/day selected on the basis of maximum tolerable dose for a period of six weeks showed very significant changes in liver weight(P<0.01) and body weight(P<0.01) in all DEHP treated groups except two weeks treated mice group . Increase in serum level of SGPT and ALP in DEHP treated group were not significant (P>0.05) in two weeks treated mice while significant(P<0.05) in four weeks and very significant (P<0.01) in six weeks treated mice .Decrease in serum level of albumin and total protein in DEHP treated mice groups were statistically not significant (P>0.05) in two weeks while found very significant (P<0.01) in four weeks and statistically extremely significant(P<0.001) in six weeks . The present study concludes hepatotoxic effects of the selected dose of DEHP (10mg/kg b.wt./day) on female swis albino mice observed as the significant biochemical changes in the liver function test parameters. Since variable concentrations of Di (2-ethylhexyl) phthalate are present in plasticizers and plastic containing consumer products it is necessary to investigate the toxic potential of DEHP.
