The present study was aimed to find an eco-friendly approach for the management of tomato early blight disease through seed treatment with different concentrations of crude oligosaccharide elicitor of Alternaria solani with PGPR alone and in combination. Seed treatment with the combination of 3 mg/ ml of CO with TN_Vel-35 showed significant increase in germination of 93.33% and 2733 seedling vigor when compared to control as well as individual treatments showing 75% germination and 887 seedling vigor. Under green house conditions maximum disease protection of 83% against early blight disease was recorded in combined treatment of CO with TN_Vel-35 when compared to control which showed less than 10%. At the biochemical level, enhanced accumulation of POX (49.86 U at 24 hpi) and PPO (44.56 U at 48 hpi) was obtained in challenge inoculated seeds treated with combined treatment of CO with TN_Vel-35 when compared to all other treatments and control.