This paper accounted for an advanced intrathecal infusion pump by using never-tried-before celebrospinal fluids compensation for pain patients by transplantation. The system provided the authentic administrations of morphine with one-way valve to cope with the problem that celebrospinal fluids flowed backward. In addition, it was possible to connect the catheters with case that the devices to hold catheter was embedded according to doctor’s advices, or to create sealed-reservoir spontaneously at the same time as combining case. Moreover it accessed about a long lasting battery life with 2 years to flow amount of morphine with 2 gram per day. Since this medical instrument has been particularly devised for the safety, biocompatibility, stability, accuracy, connectivity and durability, it was possible to be substantiated that the intrathecal pump with CSF compensation made it easy to provide lucratively and draw attention to patients with cancer pain throughout in-vivo performance and safety evaluations.