The successive extracts of Clerodendrum multiflorum stem, a traditional medicinal plant used in India. It possessed a significant amount of total phenolic and flavonoid contents with potent antioxidant activities in scavenging DPPH, ABTS radicals, and good total antioxidant capacity. On the other hand, the ethyl acetate and ethanol extracts showed the highest inhibition of DPPH, ABTS radicals and phosphomolyb date assay. This study verified that the ethyl acetate and ethanol extracts have strong antioxidant activities which might be due to high level of phenolics and flavonoids. Thus results confirms its traditional claims can be used as a source of potential antioxidant.