This work deals with the potential of radar and optical imagery in mapping favorable sites for gold and uranium prospecting in the departments of Abtouyour and Guéra. The objective of this work is to identify potential sites for gold and uranium prospecting. Landsat 9 images, Aster images and Palsar images were used as input data. The lineaments of the study area were extracted from the Palsar images and subsequently validated by geophysical data. The iron oxide index (IOF), clay mineral index (IMA), Relative Band Depth 1, 2 and 3 parameters made it possible to extract hydrothermal alteration minerals and iron oxides. Alteration minerals and iron oxides were extracted by segmentation. Then the lineament density was generated using the lineament file. Favorable sites for gold and uranium prospecting are identified based on a multi-criteria analysis combining the different alteration minerals, iron oxides and lineament density. The results obtained highlight favorable sites located in the far south, far north and central part of the province. Field studies allowed the samples to be collected and analyzed. It was also found that these sites obtained coincide with the artisanal gold mining areas.