Introduction: First aid is the treatment of any injury or sudden illness before professional medical help can be provided to prevent the condition worsening, fast recovery and preserve life. Material and Methods: An evaluative approach with one group pre-test and post-test design was used as research design in the study. Fifty participants were selected as sample by using purposive sampling technique. The data were collected using structured knowledge questionnaire and compliance check list through interview schedule. Result: The data analysis that the mean post test knowledge (18.52± 2.628) scores were apparently higher than the pre test knowledge (14.54 ±2.383) scores. The median of the post test (19) was also found to be higher than the median of the pre-test scores (15). Total post test mean Knowledge score (34.52) in all areas of first aid of selected minor injuries was higher than the total pre test mean score (27.64). the mean post test score in the areas of Psychology of children about play, Safe and healthy environment of school, Concept of First aid, First aid Box, Concept of minor injuries Management of Minor wounds, Musculoskeletal injuries Minor burn and scald, Dental injuries, Epistaxis, Minor ear and ear injuries and Application of dressing and bandages. Conclusion: The programme was highly effective in increasing knowledge and practice of primary school teachers about first aid on selected minor injuries among primary school children.