Background: Antibiotic resistance is becoming a global issue, mainly because of abuse or excessive antibiotic using in developing countries of Asia, which has aroused more attention and criticism. Methods: All data was collected from publically published official reports or via searching antibiotic resistance-related articles in PubMed. Based on the evidence and expertise, some valuable suggestion was proposed. Results: Antibiotic resistance is not only resulting from smart bacteria gene mutation, but also resulting from excessive using of antibiotic on agriculture aspect and clinical practice. Conclusions: Multiple-pipeline efforts to cut off unfair profit links and regular application indication in both infection and agriculature, may minimize antibiotic resistance at the maximum extent.
