Study of the acute toxicity of the aqueous extract of tabernanthe iboga (baill.) (apocynacea) on wistar rats

This study focused on the evaluation of Tabernanthe iboga (Baill.) acute toxicity. The lethal dose (LD50) was determined on Thirty-five Wistar rats using BERHENS and KARBER’s method. A total of seven batches of five animals including one control group were established and single doses of 392.1, 784, 71, 1000, 1570.5, 1750 and 2000 mg/kg were administered orally. The control group received distilled water. The results obtained allowed us to determine the LD50 at 1442.571 mg/kg of body weight. Therefore, Tabernanthe iboga could be classified as a low toxicity product.