The main objective of this study was to investigate the association of employee perceptions of important HR practices on their evaluations of Perceived Organizational Support which would have further effect on their work out comes in Dire Dawa University. The populations of this study were academic staff from institute of technology, school of business and economics, school of social science, school of natural science, school of Medicine and school of law which were a total number of 276 members of which 31 were department heads who were currently working. The researchers used census inquiry because of the manageable size of the study subject. Among those 276 respondents only 201 replied the questionnaire distributed. To collect the necessary data, 5 point scale Likert-type questionnaire which was adopted from the work of different. And the collected data was analyzed using descriptive statistics like mean, standard deviation and correlation analysis; to do so the researchers used SPSS latest version. The major finding of this study was that academic employee’s of the university have low perception towards Human Resource practices of the university, namely pay system (µ=1.76), career development opportunity (µ=2.48), work-family support (µ=1.86) and immediate supervisor-employee relationship (µ=2.58) contributed to low level of perceived organizational support (POS) (µ=1.9). Among HR practices POS of academic employees have strong association with Work family support (r=0.88) followed by currier development opportunity(r=o.82), pay level satisfaction (r=0.78) and immediate supervisor-employee relationship (r=0.51). They also have low commitment in helping the organization achieve its objectives (µ=2.77), have low feeling of organizational citizenship behavior (µ=1.86) and strong intention to leave the organization (µ=4). Additionally academic employees POS has positive association with employees commitment (r=0.89) and employee’s organizational citizenship behavior (r=0.82), but have significantly negative association with turnover intention (r= -0.88).
