Snail control is one of the important tools to reduce the incident of fasciolosis. To attain this objective the present study undertaken to evaluate the molluscicidal potential of Terminalia arjuna bark and Tamarindus indica seed. The toxicity of both of plants were time and concentration-dependent. The toxicity of T. indica seed (12.00 mg/l) was more pronounced than that of T. arjuna bark (57.47 mg/l). Ethanol extract of both plants were more effective than other organic solvent extract. The 96h LC50 of column purified fraction of T. arjuna bark (3.12 mg/l) and T. indica seed (0.71 mg/l) was found to be highly effective against snail. Arjunolic acid and procynadine were isolated by column chromatography and characterized as active molluscicidal components in T. arjuna bark and T. indica seed respectively. Co-migration of pure arjunolic acid (Rf 0.80) and procynadine (Rf 0.77) with column purified extract of T. arjuna bark (Rf 0.80) and T. indica seed (Rf 0.77) demonstrate the same Rf value, confirm the presence of arjunolic acid and procynadine in their respective column purified fractions. The result of the present study clearly indicate that the T. arjuna and T. indica are the potential source of plant molluscicides.