Synthesis Of Pyrido [2,3-D]Pyrimidin-2,4(3h)-Dione Nucleoside

Pyrido[2,3-d](1H,3H)-pyrimidin-2,4-dione2ribosylated with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose3 by using the silylation method, afforded anomeric of the benzoylated nucleoside 5. Debenzoylation of compound5 by sodium metal in dry methanol to afford the corresponding free nucleoside6. The structures of the newly synthesis compounds have been confirmed on the basis of elemental analyses, IR, 1HNMR, 13CNMR and Mass spectral data.