By our suggestion, the Halden, Bohr effects have implemented within Eight stage of 9 staged full closed cycle of proton conductance-located in the Respiring tissues -capillary blood which are existed around 87 trillion cells, Pulmonary circuit, where occurred oxygen unloading under effect of increased bicarbonate exit by bicarbonate/chloride ion shift mechanism, leading to increase of protons released from NADH, FADH, reduced KoQ resulting to entry of protons to erythrocyte membrane surroundings, which are inseparable parts– basic components of the System models of the Human body, including the membrane redoxy potential three state dependent 9 stepped full cycle of proton conductance and the four compartments, also the 10 functional systems, and four types of cells, distinguished by difference of proton conductance, all these processes have been connected with that as the presence of protons from peripheral tissues favors the formation of salt bridges by protonating the terminal His residue of the betta subunits, an increase in protons causes oxygen release, while an increase in oxygen causes proton release, the hydrogen ions (protons) tend to displace the oxygen from the hemoglobin,protons promote oxygen unloading, After making such new interpretation as Ninth stage - of 9 staged close cycle of proton conductance in the location of Respiratory membrane, Pulmonary circuit have been distinguished by oxygen uptake from alveolar air -under effect of increase of bicarbonate entry by bicarbonate / chloride ion shift mechanism and Eighth stage have been functioned in the level of Pulmonary circuit, Respiring tissue characterized by oxygen uploading by bicarbonate / chloride ion shift mechanism, release of oxygen from HbO2-under effect of exit of bicarbonate by bicarbonate / chloride ion shift mechanism, leading to increase of oxygen in a mitochondrial - 6-thstage was became easy to understand the scientific basis of relationship between Halden, Bohr effects and eighth and ningh stages of closed 9 staged cycle of proton, electron conductance, in such way relationship between Halden, Bohr effects and the System models ofthe Human body, including the membrane redoxy potential three state dependent 9 stepped full cycle of proton conductance and the four compartments, also the 10 functional systems, and four types of cells , distinguished by difference of proton conductance.
