The optimal management of multiple traumas involving femoral fractures and severe traumatic brain injury presents a significant clinical challenge. The treatment of these patients requires careful evaluation and a well-considered decision regarding the appropriate timing for surgical intervention for femoral fractures. This study focuses on exploring the clinical and radiological criteria guiding the decision for femoral fracture fixation in patients with severe traumatic brain injuries. By analyzing a series of 69 cases, we aim to define the indications and outcomes associated with this intervention, aiming to optimize the management of these complex and often urgent situations. Discussion: The optimal management of multiple traumas involving femoral fractures and severe traumatic brain injury presents a significant clinical challenge. The treatment of these patients requires careful evaluation and a well-considered decision regarding the appropriate timing for surgical intervention for femoral fractures. This study focuses on exploring the clinical and radiological criteria guiding the decision for femoral fracture fixation in patients with severe traumatic brain injuries. By analyzing a series of 69 cases, we aim to define the indications and outcomes associated with this intervention, aiming to optimize the management of these complex and often urgent situations.