The coronavirus (COVID-19) pandemic has demonstrated high intensity to affect human beings in the world—and how each individual responds can potentially affect everyone else. Initially observed in the Wuhan province of China, now vastly spreading around the world. In the world, the 80 percent death was recorded from Europe and American continents only. As redemption how could be improved socio-economic - health condition of the countries. This virus is known as the novel one and the aetiology and pathobiology is unable to understand. The structure of coronavirus spike protein is a multifunctional molecular machine that mediates coronavirus entry into host cells. The spike protein exists in two structurally distinct conformations, prefusion and postfusion. The pandemic corona also stroked in India has been severely spreading in all the pockets in the country. The prevention and precaution strategies are following However being a novel corona virus the treatment is not very sure due to non- availability of effective diagnostics and prophylactics like confirmed vaccine . This article reviews current knowledge about the structures and functions of coronavirus spike proteins illustrating how carriage the serious health threats to humans all over the world. Institute of Bio- Research and Human Development (I-BIRD) suggested for the improvement in the diet supplementation and the immunity to boost with proper protection measures of personal hygiene during the corona infection. Vaccination of COVID-19 has been started through health workers from January, 2021 in the India.
