Call for Papers : Volume 15, Issue 07, July 2024, Open Access; Impact Factor; Peer Reviewed Journal; Fast Publication

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Life Sciences

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An antiviral drug combinational studies against hiv- a computational drug repositioning approach

This study was aimed at identifying two promising generic drugs and conduct an antiviral drug combination studies against HIV. It has two components; computational and in-vitro studies. The computational study entails sequential screening of all FDA approved drugs (1491) against three protein targets; through structural- and ligand- based pharmacophore screening followed by molecular docking of the selected drugs against the viral targets. Two (2) drugs with the best binding affinities against the viral targets were chosen for an in-vitro confirmation of activity.

Contribution a l’etude des feuilles de melia azedarach (l.) (meliaceae): evaluation de l’activite antiplasmodiale

Melia azedarach (L.) is a tropical plant. It isused for therapeuticpurposesaround the world, especially in India. Studies have been leaded on hisbiologicalactivities. However, they are few in number. Nowadays, there are more studies of its insecticide activity or itsantifungalactivitythan on its anti-plasmodialactivity. In ourstudy, the plant material (leaves) washarvestedfrom the experimentalgarden of useful plants at the Faculty of Medicine, Pharmacy and Odontologyat the Cheikh Anta Diop University in Dakar and dried in the laboratoryawayfrom the sun.

Rp-hplc method development and validation for the estimation of simethicone in bulk and its pharmaceutical dosage form

A simple, precise, accurate and robust RP-HPLC method has been developed for the estimation of simethicone in bulk and it’s pharmaceutical dosage form. Chromatographic separation was run through a phenomenex Luna C18 (4.6 x 250mm, 5μm) column using Water: Acetonitrile: Methanol (60:20:20v/v) as the mobile phase at a flow rate of 1.0ml/min, the UV detection was observed at 270 nm. The retention time of simethicone was found to be 4.25 min. The method produce linear responses in the concentration range of 5-30 µg/ml and correlation coefficient was found to be 0.9996.

Studies on socio-economic profile, problems and constraints of shrimp farmers in Nellore District of Andhra Pradesh, India

Aquaculture over recent years has not only led to substantial socio-economic benefits such as increased nutritional levels, income, employment and foreign exchange, but has also brought vast un-utilized and under-utilized land and water resources under culture. Over the years this sector has witnessed impressive growth where culture practices have undergone considerable intensification. The Present study was carried out from 289 shrimp farmers in 32 revenue villages in 9 mandals of Nellore district.

Diagnostic study of the climatic parameters to influence the dryness of water of Lake Chad on the Chadian Area

This study is on the climatic parameters which could stimulate the rate of dryness of water from Lake Chad. It indicates that with regard to the considered parameters: duration of sunlight, temperature and relative humidity of the air, and precipitations, none has stimulated such a daily rate of dryness of 1.25 km2 of the liquid surface of Lake Chad as reported for the last fifty years.

Etude des performances epuratoires des lagunes de la station d’epuration des eaux usees de thies

Background: The mostly used type of waste water treatment plant in Senegal is the extensive ones. However, up today, they cannot satisfy the sanitation needs of the current population. Senegalese government, through its new developing program called “Plan Senegal Emergent”, is making tremendous effort in achieving up to 80% of sanitation access rate by 2030. Most waste water treatment plants in Senegal are activated sludge and lagoons, and treated waters are rejected in natural areas such as sea and soil, or used in agricultural activities.

The membrane - redox potentials three - state line system dependent - full 9 stepped cycle of proton conductance and the mechanism of entry of protons into erythrocyte membrane surroundings

The mechanism of entry of protons into erythrocyte membrane surroundings in the 8-th stage of the 9 staged closed cycle of proton conductance is needed the more detailed explanation, because cell membranes are generally impermeable to charged ions (i.e. H+, HCO3−). But should be say that during many years evolution development of organism had been formed the more appropriate way to regulate this difficulty by using the mechanism, named as exchange bicarbonate for chloride using the anion exchanger protein Band 3.

Groundwater quality assessment using chemical idices and gis mapping of karwi area, mandakini river basin, uttar pradesh, India

The paper deals with problem of water quality become more important than quantity in parts of Mandakini River Basin, Chitrakoot district, Uttar Pradesh. Based on the integrated studies, it has been observed that the lithology, geomorphology, lineaments, slope, effluents, sewage disposal, soil and land use/land cover was generated from Modis, Landsat ETM + data and Survey of India, (Nos.63 C/15 and 63 C/16; Figure 1.1) on 1:50,000 scale and integrated data with raster based Geographical Information System (GIS) to identify the groundwater quality of an area.

A study on ubiquitousness and awareness of barley health benefits for all perdurable health issues

The food constituent (Barley) that is the subject of health claim is sufficiently characterized. Cause and effect relationship has been established between the consumption of barley and lowering the different perdurable health issues. The target was general population who wants to lower their health issues. A product was developed using one as standard or reference which contain only wheat flour, other three samples were fortified with barley, flaxseed, sesame seeds and coriander leaves. Among the developed product variation-2 was highly accepted.

In vitro bio efficacy of microbial antagonists against fusarium oxysporum f.sp. vasinfectum

The bio efficacy of T. viride and P. fluorescens isolates were tested in in vitro against Fusarium oxysporum f. sp. vasinfectum causing wilt of cotton. Among the T. viride isolates, Tv7 and P.fluorescens isolates, Pf5 significantly inhibited the growth of F. oxysporum f.sp. vasinfectum tested by the dual culture technique than the control. Similarly, the culture filtrate of Tv7 and Pf5 isolates were significantly inhibits the growth of F. oxysporum f.sp. vasinfectum.