Life Sciences

Natural dyes are currently in demand not only in textile industry but in cosmetics, leather, food and pharmaceuticals. The rich biodiversity of India has provided the large amount of raw materials for natural dye extraction. Natural dyes show better biodegradability and are generally more used to with the environment. They are derived from natural resources; like plants, animals, minerals, and microbes. The majority of natural dyes need a mordanting agent (metal salt or tannins) to create an attachment between the cloth and dye.

Few Ruthenium complexes were synthesized. The structures of these complexes are characterized from XRD and spectroscopic techniques. Furthermore computational technique was used to complement the experimental structures. Three complexes were synthesized and assessed the structures of these. UV-visible titration experiment showed the binding of these complexes with CT-DNA. Antimicrobial activity of these complexes was also studies, but Ru-AT and Ru-ANP complexes are found to be good activity and Ru-ATDM complex showed no activity.

Street vending foods are readily available sources of meals for many people, but the microbiological qualities of such foods have been always in doubt. The aim of this study was to determine the microbial quality of legume and vegetable based foods and the hygienic practices of street vendors in Bahir Dar town. Sixty (60) food samples were collected from different locations. Aerobic mesophilic, total coliforms, fecal coliforms and Staphylococcus aureus counts was based on standard methods from between July 2015 and December 2015.

The goal of this study is to determine a theoretical model to define tomato drying curves. For this, a mathematical model based on the conservation of heat and mass is used. Heat and matterdiffusion equations have been developed and used in the COMSOL computation code. The theoretical model is validated by experimental measurements. The experimental data are obtained in a tunnel dryer with values of 0.1m/s, 0.25m/s and 0.5m/s for the drying air velocity and 50°C; 60°C for air temperatures.

This study was aimed at identifying generic drugs with activity against HIV. It has two components; computational and in-vitro studies. The computational study entails sequential screening of all FDA approved drugs (1491) against three protein targets; through structural- and ligand- based pharmacophore screening followed by molecular docking of the selected drugs against the viral targets. Two (2) drugs with the best binding affinities against the viral targets were chosen for an in-vitro confirmation of activity.

La région d'Oumé possède d'énormes potentialités agricole et minière. La géologie est caractérisée par un socle granito-schisteux. Un important flux migratoire y est observé du fait des nombreuses industries minières qui s'y installent. Elle est ainsi confrontée à une forte demande en eau, non satisfaite, et éventuellement à un risque de pollution de la ressource souterraine du faite que ces eaux se trouvent dans des aquifères fracturés. L’objectif de cette étude d’évaluer la productivité de l’aquifère de fractures. 167 fiches techniques de forages ont été utilisées.

La région d'Oumé possède d'énormes potentialités agricole et minière. La géologie est caractérisée par un socle granito-schisteux. Un important flux migratoire y est observé du fait des nombreuses industries minières qui s'y installent. Elle est ainsi confrontée à une forte demande en eau, non satisfaite, et éventuellement à un risque de pollution de la ressource souterraine du faite que ces eaux se trouvent dans des aquifères fracturés. L’objectif de cette étude d’évaluer la productivité de l’aquifère de fractures. 167 fiches techniques de forages ont été utilisées.

Climatic warming is effectively slowly going on in both localities. The annual means of the maximal temperature of the air increased at the rates of 0.045°C/year and 0.023°C/year and of the minimal temperature of the air,the rates of 0.032°/year and 0.013°/year in Ndjaména and Moundou respectively. The consequences should be socially and economically catastrophic. To prevent and even eradicate this warming, it is strongly recommended the creation and management of green spaces all over the cities.

This study was aimed at identifying two promising generic drugs and conduct an antiviral drug combination studies against HIV. It has two components; computational and in-vitro studies. The computational study entails sequential screening of all FDA approved drugs (1491) against three protein targets; through structural- and ligand- based pharmacophore screening followed by molecular docking of the selected drugs against the viral targets. Two (2) drugs with the best binding affinities against the viral targets were chosen for an in-vitro confirmation of activity.

Melia azedarach (L.) is a tropical plant. It isused for therapeuticpurposesaround the world, especially in India. Studies have been leaded on hisbiologicalactivities. However, they are few in number. Nowadays, there are more studies of its insecticide activity or itsantifungalactivitythan on its anti-plasmodialactivity. In ourstudy, the plant material (leaves) washarvestedfrom the experimentalgarden of useful plants at the Faculty of Medicine, Pharmacy and Odontologyat the Cheikh Anta Diop University in Dakar and dried in the laboratoryawayfrom the sun.