Objective: To investigate the clinical application value of pancreatic stomach bundled reconstruction (binding pancreaticogastrostomy, combined) in pancreatic duodenal resection (pancreaticoduodenectomy, PD). Methods: The clinical data of 16 patients with pancreaticoduodenectomy combined with pancreatic stump and gastric banding reconstruction in our department were analyzed. The incidence of postoperative complications and its causes were analyzed. Chinese sf-36 health survey scale was used to investigate health-related quality of life (HRQOL) of patients. Results: 1 case of postoperative pancreatic stump hemorrhage was cured after conservative treatment. Postoperative complications such as pancreatic leakage, biliary fistula and delayed gastric emptying were not found. The content of peritoneal drainage fluid and amylase in the peritoneal cavity of the patients decreased gradually, and the gastrointestinal function showed better recovery. All patients were cured and discharged. The quality of life of the patients in this group was better after operation. Conclusion: in pancreaticoduodenectomy, pancreaticogastric banding reconstruction has its own unique advantages. Reasonable application of pancreaticogastrostomy may reduce the incidence of postoperative pancreatic fistula in patients, and has better long-term quality of life.