Medicinal plants have rich sources of therapeutic constituents and shown beneficial therapeutic effects, including anti-oxidant, anti-inflammatory, anticancer, antimicrobial and anti-immune modulator effects. In the present investigated Aerva lanata shows predominant amount of phytochemical constituents such as alkaloids, flavones, saponin, terepenoids etc., in butanol extracts. The active compound of 2-Decyl -1-tetra decanol was isolated and confirmed by GCMS method. The active compound inhibited gram positive (Staphylococcus aureus and Micrococcus sp.,) and gram negative organisms (Klebsiella sp. and Pseudomonas aeruginosa) at the concentration of 20-35 µg/ml. It shows isolated active compound of 2-Decyl -1-tetra decanol to be used prepare plant based drugs to cure pathogenic bacterial diseases.