The compound oxazole and its derivatives are crucial to the field of medical chemistry. The oxazole nucleus is a heterocyclic five-membered ring that has been explored in an effort to develop new molecules with advantageous biological properties. In recent years, the use of oxazole as intermediates in the synthesis of novel chemical entities in medical chemistry has risen. Oxazole has sporadically been used as a functional lead molecule in contemporary pharmaceutical chemistry. Massive oxazole candidates or medications are being created often for the treatment of diseased condition, increasing their potential as therapeutic agents. Oxazoles five-membered aromatic ring contains nitrogen and oxygen atoms. These rings swiftly interact physiologically with various enzymes and receptors via a variety of non-covalent connections, leading to a range of biological functions. This review makes a rational effort to promote oxazole chemistry research and development. The significant data in this publication will serve as inspiration for fresh ideas in the quest for the rational creation of more physiologically active and less toxic derivatives of oxazoles as pharmaceutical agents.
