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Effect of aqueous extract of Eclipta alba on cadmium chloride induced hypertension in Wistar albino rats

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Author: 
*Dr. Ritu Yadav, Dr. Jai Prakash Singh, Dr. Ajay Kumar Sahu and Gaurav Sharma
Abstract: 

Objective: Hypertension is asymptomatic in nature but produces dreadful effects on the body. The causes, so also the drugs are many & usually the treatment is lifelong. Hence research is going on to find out a suitable & safe drug. Aqueous extract of Eclipta alba has been taken to see the antihypertensive effect.
Material and Methods: In the study firstly the hypertension was induced in group 1,2,3,4 by giving CdCl2 1mg/kg i.p for 15 days. After that group1 was given normal saline, group 2 and 3 was given aqueous extract of Eclipta alba at dose 100mg/kg and 200mg/kg twice a day respectively, group 4 was given amlodipine 1mg/kg O.D, The B.P. was measured on day 0th , 15 th , 30 th ,45 th day by non-invasive B.P. system for rodents.
Results: A rise in blood pressure was found on day 15thof i.p. injection of CdCl2 in all four groups. Group 3 (Aq. Extract Eclipta alba at dose 200mg/kg) found have significant changes in, Systolic and diastolic B.P. (119.17 mm/Hg and 80.83 mm/Hg) and also Group 4 (Amlodipine at dose 1mg/kg) found have significant changes in, Systolic and diastolic B.P. (119.83 mm/Hg and 78.00 mm/Hg)
Conclusion: Aqueous extract of Eclipta alba (200mg/kg B.D.) was found to posses significant anti hypertension effect in wistar albino rats.

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            Prof. Dr. ISMAIL YILDIRIM

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