Water and Nitrogen deficiency are the most important yield limiting factor in rice production. The effect of various irrigation regimes and nitrogen fertility levels on lowland rice (FARO 44) and soil properties aimed at improving water and nitrogen use efficiency was studied for two years during the dry seasons of 2011/2012 and 2012/2013 in the field at the Lake Geriyo Irrigation scheme farms, Yola, Adamawa State, Nigeria. Six Irrigation regimes involving three irrigation intervals (4, 8 and 12 days intervals referred to as I1, I2 and I3 respectively) and three irrigation withholding at different growth stages (vegetative, reproductive and repining stage referred to as I4, I5 and I6 respectively) with four nitrogen fertility levels (0, 50, 100 and 150kg N ha-1 referred to as N0, N1, N2 and N3 respectively) were imposed in a split plot design, replicated three times. The results showed that grain yield, N concentration in grain and straw and uptake were higher in 4 days irrigation interval and 150 kg N ha-1treatments (I1N3). Higher agronomic nitrogen use efficiency (24.85 kg kg-1) was recorded in I2N1 treatments and partial factor productivity of nitrogen (93.78 kg kg-1) under I1N1 treatments. N uptake increased with increased in the N application levels. It can be concluded that rice may be grown on clay loam soils of Adamawa State, with irrigation interval of between 4 to 8 days and irrigation withholding at ripening stage with 100 – 150kg N ha-1 to achieve higher N uptake and yield.