Background: Down syndrome is characterized by general mental and physical disorders, or by isolated walking, cognitive, growth, or sensory disorders. Objective: The study examined the impact of an integrated sensory approach on the improvement of balance and motor coordination in children suffering from Down syndrome. Methods: Thirty children were randomly divided into two categories: group A received a combination of sensory integration and physical therapy, Group B received only the physiotherapy program. The motor skill and balance were assessedprior to and following the exercise by the Bruininks - Oseretsky Test of Motor Competence - 2nd Edition. Results: The data evaluation was performed in 30participants suffering from Down syndrome using a t-test in pairs to assess the variations in pre- and post-test scores and effect size. Statistical significance was determined at p < 0.05. The group's results before and after treatment showed significant improvements in forward walking, upper-limb coordination, ball retrieval capacity, and agility (p = 0.0001). Conclusions: It is recommended to add a sensory integration program to specific physical therapy for enhancing the balance and coordination of motor function in those suffering from Down syndrome. Therefore, this practical approach should be used as an option for effective intervention.