The main purpose of this study was to assess the factors that affect the business performance of women entrepreneurs in small and medium enterprise (SMEs). A survey methodology using simple random sampling was carried out, covering the women entrepreneurs that registered under SME Corporation. A structured questionnaire was then distributed to 100 out of 120 women entrepreneurs. In this study, MANOVA was used to examine whether economic factor, social factor, legal/administrative factor and business performance significantly differ among three business sectors (1: Trade, 2: Production, 3: Services). The result was significant, revealed that there are significant difference in economic factor, social factor and business performance among three business sectors stated above. Then, the path analysis in structural equation modeling was employed to examine the effect of economic factor, social factor and legal/administrative factor towards the business performance of women entrepreneurs in SMEs. The results implied that only social factor significantly influence business performance of women entreprenuers in SMEs. While economic factor and legal/administrative factor were not significantly influence business performance of women entrepreneurs in SMEs at 5% level of significance. Therefore, based on this study, it revealed that only social factor significantly affect the business performance of women entrepreneurs in SMEs.