COVID-19 emerged in December / 2019 in China and became a global crisis that requires strategies such as social isolation, increased testing and vaccination. In a descriptive, cross-sectional, and quantitative epidemiological study, based on secondary data, collected by the public database of the Tenth Regional Health Department of the State of Pará, 11.693 diagnosed cases of infection by the SARS-CoV-2 virus were analyzed between April and September, 2020, in a region in the Brazilian Amazon. It was found that 396 people needed hospitalization and 260 died. Among the infected group, women had a 5.8% higher prevalence compared to the number of men. In addition, individuals aged 30 to 39 years made up most of the sick population with COVID-19. It was observed that all municipalities in the region faced, in the analyzed period, a calamitous epidemic situation, with a high rate of viral transmission, a significant number of deaths and little capacity to cope with the health crisis. Another peculiar point concerns the way of life of urban, traditional, and riverside communities in the Amazon, which relate in different ways, impacting the spread of COVID-19. Thus, these analyzes demand a closer look at COVID-19 in the region, to avoid an even more pernicious outcome for the ongoing crisis.
