Call for Papers : Volume 15, Issue 03, March 2024, Open Access; Impact Factor; Peer Reviewed Journal; Fast Publication

Natural   Natural   Natural   Natural   Natural  

Ethanol extract of herb sage suppressed the timp-1 expression in lymphoid culture cells

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We aimed to determine the effects of food herbs and spices on several gene expressions. Some herbs and/or spices are found to have a potent transcriptional suppressor activity for the tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) gene. The in vitro effect of the herb Sage ethanol extract on the expression of TIMP-1 was confirmed by reverse transcriptase-polymerase chain reaction (RT-PCR). Western blotting also confirmed the down-regulation of the protein at dose dependent manner of Sage extract in lymphoid Jurkat cell line cells.

Author: 
Naoko Okumura, Yuri Nishimura, Hitomi Yoshida, Yuka Nagata, Yasuko Kitagishi, Satoru Matsuda
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