Solanum melongena (SM) or eggplant and Solanum lycopersicum belongs to the family Solanaceae. The present research work investigates the effects of combination of both extracts for analgesics and inflammatory activities. Fresh leaves were collected, weighed, grinded and mixed into fine powder followed for Soxhlet extraction using hydro-alcohol (50-50%) as solvent. The analgesic and anti-inflammatory activities were investigated using eddy’s hot plate method and formalin induced paw oedema model using plethysmograph. Albino Wistar rats of either sex were divided into 4 groups each containing six animals where control group is treated with saline, standard group with (diclofenac sodium 10mg/kg-i.p.), test groups with hydro-alcoholic leaf extract of Solanum melongena and Solanum lycopersicum at doses 150mg/kg and 300 mg/kg (orally). The extracts showed significant analgesic and anti-inflammatory activity at the dose of 300mg/kg with respect to standard drug diclofenac sodium (10mg/kg). Analgesic activity using eddy’s hot plate method screened based on time taken to show pricking and licking movements showed significant analgesic activity at 300 mg/kg (9.08±0.19sec) similar with standard drug (8.9±0.39sec). Anti-inflammatory activity screened using formalin 5% (0.01ml) induced paw edema model. Standard group showed 77.61% decline in inflammation whereas the group receiving 300mg/kg also showed 73.77% decrease in inflammatory response measured using rise in mercury levels. The results indicate the leaf extracts at doses of 300mg/kg showed good analgesic and inflammatory activity due to synergistic effect.
