The universities in Malaysia indirectly contribute to the nation’s future development by developing a pool of professionally educated and trained employees. Therefore, in general it is undeniable that the role of lecturers is really important in producing a quality graduate who will in turn brings up the nation ahead since the educated graduates are the assets of one country. The main purpose of the study is to investigate certain factors influencing on job satisfaction, namely workload, work-place environment and relationship with colleagues. The study used self administered questionnaires which were distributed to 245 lecturers from UTHM. The data was analyzed using SPSS 19 for preliminary analysis while AMOS 18 was used for Structural Equation Modeling (SEM). The study found that workload (WL) and relationship with colleagues (RC) have significantly affected to job satisfaction of lecturers.