Nanomaterial surfaces based sensing platform for highly sensitive impedimetric dna detection: a critical review

Advancement innanoscience & nanotechnology hasled to parallel increase in fabrication of newer, improved nanomaterials. Recent trends in nanotechnology is emphasized on generating novel nanomaterials with attomolar efficiencyby employing combination of polymer and nanomaterial. The present review demonstrates the status quo of progress in fabrication of sensing materials and sensing efficiency of DNA sensors (genosensors) that utilizes electrochemical impedance spectroscopy as a transduction technique. This reviewis centered on the use of nanomaterials or developing and improvising the performance of these specific biosensors. It covers the different principles that are used in the measurements and detection of DNA sequence or in amplification of finally obtained signal. The use of nanomaterials for the above listed aspects, viz., use of carbon nanotubes or other nanoscopic elements in the construction of the electrodes and usage of metallic nanomaterials, polymeric nanoparticles and mesoporous materials for signal enhancement,are thoroughly summarized in this review.