The potential regarding antioxidant activity of Moracin has been assessed through the use of hydrogen peroxide induced stress in skin fibroblast cell line culture (AH927). The results of the attempt showed that the Moracin offers protection against oxidative stress. And cell viability was found restored to that of control on pre-incubation with the Moracin. The fibroblasts pre-incubated with Moracin had significantly lower levels of catalase; lactate dehydrogenase and malondialdehyde activity when compared to untreated ones. This attempt indicates that, the Moracin is serving as a valuable antioxidant source and therefore, it may be used to treat the cancer cells. The present attempt suggests that acetone-soluble (and water- soluble too) Moracin, from a natural source the fruits of mulberry, Morus alba (L), serve as ideal molecule to prevent oxidative stress.