Call for Papers : Volume 15, Issue 12, December 2024, Open Access; Impact Factor; Peer Reviewed Journal; Fast Publication

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Phenolics compounds isolated from ximenia americana l. (olacaceae) trunk bark used in the traditional treatment of hypertension

Ximenia americana L. (X. americana) is a medicinal shrub used in Niger and West Africa for the treatment of various diseases, the most common of which are infectious, inflammatory, and viral diseases. Particularly in Niger, the trunk bark of this plant is use in the traditional treatment of hypertension.Our study aims to identify phenolic compounds with antihypertensive or antioxidant properties of extracts of the trunk bark of this plant by extraction, then fractionation with solvents of increasing polarity (respectively hexane, chloroform, ethyl acetate and n-butanol) and purification by chromatography (normal open column and TLC). The resonance magnetic nuclear (RMN) analyses 1D (1H AND 13C) and 2D (HMQC, HMBC, DEPT) allowed to determine the structure of pyrogallol (compound1), protocatechuic acid (compound 2), catechol (compound 3) and epicatechin ( compound 4). These novel compounds of X. americana L. bark were isolated for the first time.The presence of these compounds in this plant could justify its use in the traditional management of hypertension.

Author: 
ZAKARI SEYBOU Djamilatou, VIRIEUX David, PIRAT Jean Luc and SABO Haoua Seini
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