Objective: The aim of the current study was to evaluate the cardioprotective effect of the methanolic extract of Ruellia tuberosa on doxorubicin induced cardiotoxicity. Methodology: For cardiotoxicity, thirty rats were evenly divided into 5 groups. Groups-1 served as Normal,Group-2 control drug treated group, Group-3 vitamin-E treated group, Group-4 test drug(low dose) treated group, Group-5 test drug(high dose) treated group, and treatment is given for 8 days, On 5th day need to induce cardio toxicity with 5 fluorouracil, then on 9th day need to sacrifices rat then blood samples is taken for lipid profile test, and the rat heart for histopathology were obtained under inhaled diethyl ether anesthesia. Result: administration of 5 fluorouracil in control rats showed a significant increase serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), and decrease in high density lipoprotein (HDL).Rats treated with hydromethanolic extract of Ruellia tuberosa (250 mg/kg and 500 mg/kg) showed decreased TC, TG, LDL and increases HDL levels. The histopathological studies also showed that the plant extract significantly minimized the damage induced by % fluorouracil. Conclusion: Thus, Ruellia tuberosa provide cardio protection against 5 fluorouracil induced MI in rates.
