Aim: To study the prescribing pattern of General Practitioners in a Semi Urban Area. Methodology and Results: In this study, a total of 500 prescriptions were collected from the general practitioners of Viluppuram, a semi urban area and analyzed using WHO/INRUD indicators. There were average 3.5 drugs per Prescription. Drugs were prescribed in generic name only in 0.32%. About 52% drugs were prescribed from Essential drug list, only 21% of prescriptions were complete in respect to patient medication information. Antibiotics were prescribed in 70% of prescription; injection were prescribed in about 9.25% of the prescription. Conclusion: There was poly pharmacy, decreased use of drugs from EDL, increased use of antibiotics and reduction in patient medical information in our study.