A series of novel metal complexes of general formula [ML2]Cl2 and [CrL2Cl2]Cl where M is Cu(II), Co(II) and L is a Schiff base formed by condensation of dihydropyrimidone derivative of vanillin (Biginelli Product) and 4-aminoantipyrine have been prepared and characterized by analytical, spectral, magnetic and conductance measurements. Magnetic measurements and electronic spectral studies suggest an octahedral structure for the Cr(III) complex and square planar geometry for Cu(II) and Co(II) complexes. The data show that the complexes have composition of the ML2 type. The antimicrobial screening of the ligand and its complexes have been extensively studied on bacterias like E.coli, Vibrio spp., Staphylococcus aureus, Pseudomonas aeroginosa, Bacillus spp., Vibrio parahaemolytics, Salmonella spp., Aeromonas spp., Klebsiella spp., Proteus spp. and fungi such as Candida albicans, Aspergillus flavus, Pencillium spp., Aspergillus niger, Trichophyton. The results also indicate that the metal complexes are better antimicrobial agents as compared to the Parent Schiff base ligand and Biginelli product.
