Gridhrasi is such a disease, which carry little threat to life and interfere greatly with living also. The person who suffers from this disease is particularly handicapped, as he can’t walk, stand or sit properly and the painful limb continuously draws his attention. The management provided by modern medicine for this condition is either conservative like rest, immobilization, analgesic and anti-inflammatory drugs, physiotherapy, manipulation etc. or surgical. If the pain and neurological findings do not disappear on prolonged conservative treatment, finally they go on surgery, which is also not the ultimate solution as there is a common problem of recurrence or some patients lose their working capabilities. Acharya Charaka has described Basti, Siravyadha (Venepuncture) and Agnikarma in the management of Gridhrasi. In this present study, 30 patients were observed randomly during this classical method for treating Gridhrasi (Sciatica). These 30 patients were divided in two groups on the basis of treatment Procedures. In Group I Siravedhana (Blood Letting) was performed and in another group II, Agnikarma Procedure was done on patients as per classical established method adopted by Ayurveda Acharya.