Objectives: Pathological effects of teething mixture syrup (par aminophenol and diphenhydramine hydrochloric acid) and teething powder (Matricaria recutita) on the gastrointestinal tract, lungs, liver and kidneys of wistar rats. Study design: Fifty four adult wistar rats of both sexes, were divided into six groups of nine rats per cage. Group A served as control, groups B, C and D received half doses 0.42(ml/kg body weight), normal dose 0.83(ml/kg body weight) and double dose 1.67(ml/kg body weight) of teething mixture syrup while groups E and F received normal dose 0.67(mg/kg body weight) and double dose 1.33(mg/kg body weight) of teething powder respectively. Three rats were sacrificed from each group at three weeks intervals, for histopathology studies and biochemical analyses. Results: Revealed significant decrease in the percentage mean body weight increase of all the groups that received teething powder, (P<0.001). Histomorphologic changes occured in the stomach, liver and kidney of the rats treated with normal and double doses of both teething substances. Biochemical analyses revealed significant increase in the serum total billirubin and alkaline phosphatase activities of the rats treated with both teething substance (P <0.05). Conclusion: The administration of both teething substances revealed dose and duration related adverse effects.
