Now days among many serious diseases, cancer plays very important challenge to human society. To prevent this disease, many target proteins have identified. Among them MMP9 is playing very important role. Matrix metalloproteinase belong to the large family of protease known as the metzincin super family, These are zinc dependent endopeptidases. MMP have capacity to degrading all kind of extracellular metrix. Matrix metalloprotease 9 is a type iv collagenase is a class of enzyme belongs to the family of metalloproteinase involved in degradation of extracellular metrix. 20W1 is the available tertiary structure which was found in Protein Data Bank (PDB). The structure was taken for refinement by using PyMol and inhibitors were found from different literature study. The protein 20W1 was bound with some of its inhibiters and the binding energy, bond length with its interacting residues are studied.
