Grewia orbiculata of family TILICEAE is widely used in the traditional medicine for the various diseases. In present study, the plant parts (leaves) were shade dried and phytochemicals were extracted with polarity based solvents like hexane, ethylacetate and methanol. The three different extracts showed great variation in terms of phytochemical composition. The various phytochemicals in leaf includes Alkaloids, tannins, terpenoids, flavonoids saponins. These wide range of chemical constituents and these can be useful for drug discovery and development of various new formulations. Among the three different solvent extracts, ethyl acetate extract showed strong thrombolytic activity.